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These findings suggest that GLP-1RAs, like NLY01, can lessen AD pathology by targeting neuroinflammation related to microglial activation and reactive astrocytes, thus restoring memory functions and offering neuroprotective benefits [50]

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Beyond physiologic sources, pharmacologic 1 C supplementationincluding intravenous formate and oral methanol as a formate pro-drug (with deuterated variants for kinetic control)raises circulating formate and synergizes with antiPD-1, markedly increasing the durability of tumor regressions in MC38 and other models [52]