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Examples include Tryptyr (acoltremon) , a first-in-class TRPM8 thermoreceptor agonist indicated for the treatment of the signs and symptoms of dry eye disease, and BRINSUPRI (brensocatib) , a first-in-class oral DPP1 inhibitor for non-cystic fibrosis bronchiectasis (NCFB), offering new treatment options for diseases that previously lacked effective therapies

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