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Beyond its hypnotic effect, the DSIP DSIP exhibits documented pleiotropic properties: analgesic action via modulation of endogenous opioid pathways, anti-stress effects through the reduction of cortisol and ACTH, antioxidant and neuroprotective properties, and modulation of tolerance to ethanol and addictive substances

El agonismo GIP potencia el efecto incretnico y anorexiante de GLP-1 a nivel central, reduciendo el desarrollo de nuseas (tabla 2)1,3,5

The review also documented how GCL expression is transcriptionally upregulated by electrophiles through antioxidant response elements (ARE/EpRE) in the GCLC and GCLM promoters establishing the Nrf2/ARE pathway as the master regulator of GSH biosynthetic capacity under stress conditions

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