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Our experiments have elucidated a coordinated mechanism underlying this phenomenon, characterized by the rapid induction of ISR and oxidative stress response (OSR), accompanied by increased GDF15 and FGF21, and a reduction in CoA levels resulting in metabolic inefficiency, therefore offering insights for potential intervention in metabolic diseases and body-weight control

could be detected corroborating the studies showing absence of GSH synthesis in lactococci but possessing the ability to import and regenerate reduced glutathione

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