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FINEARTS-HF enrolled participants with symptomatic HF, LVEF 40%, elevated natriuretic peptides, and evidence of structural heart disease across 37 countries

Conclusions GLP-1 RAs therapy was overall not significantly associated with incident arrhythmias in diabetic and obese patients, suggesting an assuring cardiovascular safety profile

Weight gain in men is commonly caused by a Testosterone deficiency, because Testosterone promotes muscle gain and may suppress increased fat buildup, among other functions

In the context of MASLD, glucagon receptor activation may complement GLP-1 RA by promoting hepatic fatty acid oxidation and suppressing lipogenesis, thereby reducing intrahepatic fat accumulation