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Lancet 388 , 24032415 (2016)

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This resistance, researchers write, likely stems from concerns regarding high annual costs and the lack of immediate ROI. About 60% of survey respondents are not considering changes to their GLP-1 coverage in the near term, researchers say, suggesting these organizations are either satisfied with their current restrictive posture or are being intentional about changing plans until more data emerges about both costs and health outcomes

105,106 ME2 is frequently hemizygously codeleted along with tumor suppressor SMAD4 in human solid tumors including gastric cancer and PDAC