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The age-related decline in melatonin and dampening of circadian rhythms likely contributes to sleep problems, metabolic and cognitive decline, and increased vulnerability to age-related diseases

Although oxidative stress is significantly increased in the presence of microvascular complications [19], it is not clear if patients with complications have more impaired glutathione metabolism compared to diabetic patients without complications

Labeling was strongest in symbiosomes with mature bacteroids from cells in the nitrogen fixation zone (Figures 1JL, 5B) and weakest in senescent bacteroids (Figure 4C and Table 2)

PMID: 12809732