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In this Review, we posit that eight molecular hallmarks are common denominators in cardiovascular ageing, namely disabled macroautophagy, loss of proteostasis, genomic instability (in particular, clonal haematopoiesis of indeterminate potential), epigenetic alterations, mitochondrial dysfunction, cell senescence, dysregulated neurohormonal signalling and inflammation

Stroke and ferroptosis Following ischemic or hemorrhagic stroke, neurons can undergo ferroptosis due to elevated extracellular glutamate concentrations inhibiting system Xc function [263]

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doi: 10.1126/scitranslmed.aax9106 223 KitamuraRAMaxwellKGYeWKriesKBrownCMAugsornworawatPet al