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Note that the only significant deviation of GSH in Panel B of Figure 2 occurs during days 10-14 when estradiol and S become very high, thus depressing the GSH concentration [Table 1]

Shankar R., Senthilkumar K., Kolandaivel P., International Journal of Quantum Chemistry , 2009 , 109 , 764

By reducing body fat and improving insulin sensitivity, they address the aromatase-driven suppression at its source allowing the hypothalamic-pituitary-gonadal axis to recover naturally, without substituting external testosterone for the body's own production

This finding is clinically significant for a patient population like ours in Doral, where the majority of patients present with Fitzpatrick III, IV, and V skin tones