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Resting wild-type FoB are instead characterized by downregulation of mTORC1 and its downstream targets 37,38,39 , which is indicative of metabolic quiescence

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The results were calculated based on the data obtained from three independent experiments, each of which contained six replicate reactions

Several distinct populations of microglia and macrophages have been described in the aging brain, including dark microglia (Kaya et al., 2022), and senescent-like microglia (Gross et al., 2025), underlying the heterogeneity of immune cell responses to aging-related stress