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About the GEMINI-1 Clinical Trial The GEMINI-1 clinical trial was a multi-center, randomized, double-blind, placebo-controlled Phase 3 clinical study (NCT06396429) conducted by Hengrui in China to evaluate the efficacy and safety of HRS9531 injection in adults (18 years of age) with obesity (BMI 28 kg/m 2 ) or overweight (BMI 24 kg/m 2 ) and at least one weight-related comorbidity without diabetes

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Commonly Reported Topamax Side Effects Abdominal pain Abnormal vision Anorexia Burning or prickling in the hands, arms, legs and feet (paresthesia) Diarrhea Difficulty with memory Dizziness Fatigue/sleepiness Fever Nausea Nervousness Numbness (hypoesthesia) Slowing down of thought and movements (psychomotor slowing) Speech problems Taste change Upper respiratory tract infection Weight loss Serious Side Effects Topamax may also cause rare but serious side effects such as eye complications, metabolic acidosis and kidney stones

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