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Many people dont consume enough Vitamin B12 in their diet and therefore experience a vitamin B12 deficiency, those who follow a vegetarian and vegan diet for example

If you imagine muscle as target tissue, impaired T4 to T3 conversion would mean hypothyroidism in muscle, with poor activation of the mitochondria and consequently low ATP levels (explaining fatigue and PEM)

These critical responsibilities make optimal glutathione levels vital for overall health and longevity

On one hand, betaine lowers levels of homocysteine, which when high can contribute to atherosclerosis (the buildup of plaque in the arteries)