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In the landmark UK Prospective Diabetes Study (UKPDS) , metformin use in overweight patients with type 2 diabetes significantly reduced diabetes-related endpoints, myocardial infarction, and all-cause mortality compared with conventional therapy, effects that persisted on long-term follow-up (Lamanna et al., 2011

The net effect on any individual patient depends on the balance between potential adverse effects and the benefits of weight reduction

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Influence of maternal age on meiotic spindle assembly in oocytes from naturally cycling women