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Decrease in Serum Bicarbonate In a trial of concomitant therapy of FARXIGA 10 mg with exenatide extended-release (on a background of metformin) in adults, four patients (1.7%) on concomitant therapy had a serum bicarbonate value of less than or equal to 13 mEq/L compared to one each (0.4%) in the FARXIGA and exenatide-extended release treatment groups [see Warnings and Precautions (5.1)]

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Conversely, in patients with anorexia nervosa, even supra-physiologic GH doses (mean maximum daily dose: 1.4 mg/day) may not be sufficient to normalize IGF-I levels (61) indicating the important role of hepatic GH sensitivity in successful IGF-I generation

The point is that none of them are