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The loss of GSH disrupts redox homeostasis, leading to ROS accumulation and, subsequently, cellular dysfunction and death [10]

Dark spots medically called hyperpigmentation happen when certain areas of skin produce more melanin than usual

In contrast, adult-onset deletion of the Keap1 gene exclusively in renal tubular cells caused no abnormalities in renal structure or function [67], demonstrating that overactivation of Nrf2 in the mature renal epithelium makes kidneys resistant to oxidative injuries without any significant abnormalities