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As of mid-2019, no reliable data from randomized controlled trials have shown that targeting Lp(a) reduction with medication is an effective risk-reduction strategy

Monitoring critical metrics and routine follow-ups ensure ongoing advancement and timely therapy modifications

IONIS-AGT-LRx is an ASO that hybridizes with AGT mRNA, leading to its degradation via an RNase H1-dependent mechanism and a subsequent reduction in AGT protein production