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Diagnosis should include serum B12 levels interpreted in clinical context, full blood count, and where appropriate, intrinsic factor antibodies and parietal cell antibodies

Thioredoxin (Trx), present in the cytosol as Trx1 and in mitochondria as Trx2, is oxidized and upregulated in response to oxidative stress and elevated ROS levels

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Garadacimab 200 mg subcutaneous once monthly provided early and durable protection against HAE attacks with a favourable safety profile