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In summary, fixed ratio combination of GLP-1RA and basal insulin are potentially helpful tools for the treatment of patients with T2DM as a result of its favorable safety and efficacy profile, particularly in patients who are overweight and uncontrolled on OADs or basal insulin

Bannuru, M

The body breaks down tirzepatide into smaller components, known as metabolites, which are then excreted primarily through urine and feces

The predominance of primary care prescribing suggests that the oral formulation may lower barriers to use outside of specialty care, aligning with its potential to broaden access to obesity treatment