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P-selectin in particular, which is elevated in SCD, is crucial for the sickle red cells' static adhesion to the artery wall and the subsequent vascular occlusion seen in emergencies or inflammatory conditions

Others come to it from wound-healing, connective-tissue, or barrier-model work where inflammation and remodeling are both part of the endpoint

We combine orthogonal analytical approaches to confirm composition, assess purity, and provide structure-relevant evidence that supports metabolite assignment, method development, or repeat synthesis decisions

Zoughaib WS, Hoffman RL, Yates BA, Moorthi RN, Lim K, Coggan AR