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However, the foundational mechanism paper (Benoist et al., 2014 in J Pharmacol Exp Ther) establishing Dihexas HGF/c-Met pathway activation was formally retracted in April 2025 after being flagged since 2021

- Amphotericin B: by the increase in potassium depletion - Diuretics that produce potassium depletion (thiazides, furosemide) by increasing the potassium depletion and the risk of severe hypokalemia

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Higher total cost when you factor in medication separately