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IGF1 LR3 increases lipolysis (fat breakdown) and enhances glucose metabolism
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Particularly, selective autophagy including nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy, Ras-related protein Rab7a (Rab7)-mediated lipophagy, p62-mediated clockophagy and Hsp90-mediated CMA, degrades ferritin, lipid droplets, aryl hydrocarbon receptor nuclear translocator-like protein 1 and GPX4 to induce iron overload and/or lipid peroxidation, eventually promoting ferroptosis (Fig