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Consequently, the impact of metabolic reprogramming, particularly ammonium metabolism, on TIICs within the TME warrants further investigation

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The study reported that participants "regained two-thirds of their prior weight loss." A meaningful share of the loss is muscle: across body-composition studies, roughly a quarter of the weight lost is lean mass (muscle), with the rest fat (Karakasis and colleagues, network meta-analysis, Metabolism , 2024), and the honest range landing between about 15% and 40% (Hierholzer and colleagues, review, 2026)