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GLP-1 analogues as adjunctive therapy for type 1 diabetes: systematic review and meta-analysis (24 RCTs, N=3,377)

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A 2023 study of more than 17,000 patients published in the New England Journal of Medicine found that semaglutide reduced the risk of major cardiovascular events including heart attack, stroke and cardiovascular death by about 20% in overweight or obese adults who already have cardiovascular disease but not diabetes

Many patients feel refreshed and noticeably more clear-headed immediately following treatment, while others experience a gradual improvement in vitality, mood, and cognition in the subsequent days