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This multi-receptor mechanism distinguishes it from earlier weight-management medicines such as semaglutide (Wegovy) or tirzepatide (Mounjaro), and it also explains why gastrointestinal effects including changes to bowel habits are among the most frequently reported experiences in clinical trials

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The tolerogenic mechanism is elegant: by presenting histone epitopes in a context that promotes regulatory rather than effector T cell responses, these peptides essentially re-educate the immune system to tolerate its own nuclear components