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GSK-3 down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress

However, following the supplementation of NAD +, the related damage was reversed by means of upregulating SIRT1 and SIRT3 activity, which resulted in increased mitochondrial complex content and activity, in addition to improved liver FAO and oxidative stress (Gariani et al