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Besides, not all elder T2DM patients have cardiovascular risks, and there are explicit evidences that SGLT-2 inhibitors can increase the risks of urinary tract infection and genital infection

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In the CIA mouse model, resistance of TNF-induced synovial fibroblasts to ferroptosis can be eliminated by adding a low dose of IKE (20 mg/kg, twice a week) and a low dose of TNF inhibitor