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That may be beneficial for people with low levels of IGF-1, but if your levels are already elevated from an undiagnosed pituitary issue or just natural variation in biology it could raise your risk for certain cancers and metabolic conditions

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In pregnant and breastfeeding women, vitamin B12 deficiency might cause neural tube defects, developmental delays, failure to thrive, and anemia in offspring

SAMe is biochemically produced through the folate-methionine cycle (see Figure 1), requiring many nutrients, including vitamin B12 and the healthy conversion of folic acid to 5-methyltetrahydrofolate (Guildford, n.d.)