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Some carriers (true ceramics and pure titanium) remain in the bone tissue, whereas others (collagen and synthetic polymers) are absorbed

In tests on mice and rats it worked fantastically , substantial reduction of adipose tissue, no effect on the growth axis, no insulin resistance

Most absorption problems aren't treatable but a few are - notably h pylori infection - which would mean that once that has been dealt with you would be able to absorb B12 from your diet so wouldn't need maintenance shots for life

How long you feel the effects can depend on your starting levels, which is why people with a larger deficiency sometimes notice the benefits over a longer stretch