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A February 2026 study in the Journal of Clinical Endocrinology & Metabolism found an 11% higher fragility fracture risk in older adults with Type 2 diabetes using GLP-1 medications versus those using other diabetes medications - though this was a retrospective study documenting association, not proven causation

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In the case of animals inoculated peripherally with scrapie, the agent propagates along peripheral sensory and autonomic nerves in the peritoneum to enter the spinal cord and medulla, and then ascends to invade the brain (Kimberlin and Walker, 1982)