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When we are confronted with consults about toxidromes on the nephrology consult service, acetaminophen toxicity is not the first thing that springs to our minds

Hypoglycaemia , or low blood sugar is more common in people taking insulin or certain diabetes medications, but it can happen to those using GLP-1 injections like semaglutide (Wegovy) or tirzepatide (Mounjaro) for weight loss too

Regarding HR repair, the mechanism appears to be independent of wild-type p53 and DDR signaling, since Rho inhibition does not affect BRCA1 phosphorylation (an early marker for HR repair) but increases Rad51 expression instead

Some choose to return weekly, while others prefer to return less frequently due lifestyle and work