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After setbacks in internal oral GLP-1 development, Pfizer moved to strengthen its position through acquisition activity, including its move for Metsera and its next-generation obesity portfolio

From a safety standpoint, retatrutide's known adverse effect profile from phase II trials includes: Nausea, vomiting, and diarrhoea (gastrointestinal effects common to GLP-1 receptor agonists) Reduced appetite and potential nutritional deficiencies with prolonged use Elevated heart rate observed in some trial participants Pancreatitis and gallbladder disease , which are recognised class cautions for GLP-1based therapies and should be considered in the context of retatrutide, although retatrutide-specific data remain limited Thyroid C-cell changes , observed in rodent studies with GLP-1 receptor agonists

It is an intriguing source of bioactive components, including cynaropicrin, phenolics, minerals, inulin, fiber, and sesquiterpene lactones, making it a functional food with great nutritional value

GPhC Registered Premises 1040582 , a regulated UK pharmacy