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For example, multiple preclinical studies have confirmed that engineered Lactococcus lactis and other engineered strains of different genera have not caused significant pathological damage to rat or mouse models

PET imaging studies also showed that reductions in putamen DAT levels in PLWH were associated with poorer performance on neuropsychological tests (Chang et al., 2008), and postmortem studies showed that abnormal synaptic expression of dopamine receptors and DAT in the PFC of PLWH was linked to neuroimmune activation and increased disease severity (Gelman et al., 2006, 2012)

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