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There is a necessity to further improve carrier design and adopt rational research strategies, aiming to develop more DDS based on PTT (Zhao et al., 2022b), electrodynamic therapy (Qiao et al., 2022), radiodynamic therapy (Matsuyama et al., 2022), magnetic hyperthermia (Vangijzegem et al., 2023), immunotherapy (Lu et al., 2024), and gene nanotherapy ( While ORI faces certain challenges in drug development, its therapeutic potential remains significant

Increased mitochondrial import of malate may enhance complex I activity, leading to elevated mitochondrial ATP production

Sakaki et al., 1986)