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GSH in Cancer Dual Roles in Carcinogenesis and Drug Resistance (PubMed, 2019) Elevated Tumour GSH as a Driver of Chemotherapy Resistance A comprehensive review published on PubMed examined GSHs dual roles in cancer biology chemopreventive in normal cells through carcinogen detoxification by GST, and pathogenic in tumour cells where elevated GSH levels are associated with tumour progression and increased resistance to chemotherapeutic drugs and radiotherapy

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GHS-R1b is a truncated splice variant containing only five transmembrane domains that does not signal in response to ghrelin or GHRPs, but it does heterodimerize with GHS-R1a and attenuate its signaling efficiency in a dominant-negative manner