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Reduced IDO1 is associated with the progression of colonic inflammation in mice, and supplementation with tryptophan (Trp) or an AhR agonist can ameliorate intestinal inflammation, suggesting that this pathway may have important clinical value in the treatment of IBD (94, 95)

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[12, 13, 14] Although this approach has mainly been used in cancer immunotherapy to activate cytotoxic T lymphocytes (CTLs) against tumor antigens, several immunogenic peptide therapeutics have been developed as well for autoimmune diseases including SLE, [15,16] rheumatoid arthritis, [17,18] type 1 diabetes, [19,20] and multiple sclerosis, [21] with varying success

Its quieting the food noise while we work on the psychological relationship with food