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Medical guidelines advise stopping GLP-1 drugs at least one or two months before pregnancy, and "our study cannot on its own change such recommendations," said Dr

Data were pooled for glucagon-like peptide 1 (GLP-1) receptor agonists and dipeptidyl-peptidase 4 (DPP-4) inhibitors in comparison with their respective controls and expressed as exposure-adjusted incidence rates

this research could inform the potential and limitations of those drugs

This could mean using baseline stool analyses to guide therapy selection for example, a PD patient lacking SCFA-producers might benefit most from a butyrate-producing probiotic, whereas one with high Enterobacteriaceae might need a targeted phage or antibiotic to reduce endotoxin load