glp 1 compared to ozempic GLP-1 Agonists for Weight Loss: A Side-by-Side Comparison 1 in 8 adults has

Despite this potential, given the known long-term benefit of lowering hemoglobin A1c in preventing DR progression, there does not appear to be any contraindication to initiating GLP-1/GIP agonist therapy with appropriate ocular monitoring

The choice depends on individual objectives and tolerance profiles

But heres what we know from recent research: A 2025 study presented at ENDO showed that postmenopausal women using tirzepatide plus hormone replacement therapy (HRT) lost significantly more weight (17% total body weight) compared to women using tirzepatide alone (14%)

If an antidote is not given within 8 hours and hepatotoxicity develops, it is associated with prolonged prothrombin time (PT) and elevation of transaminases (commonly into the thousands)