To achieve blood levels of at least 30 ng/mL, adults living at temperate latitudes (think: anywhere with distinct seasons) need 800 to 1,000 IU per day, ideally from vitamin D3, which is more effective than D2
On the other hand, GGCT overexpression enhances the metabolic flux of Glc into TCA cycle, providing sufficient energy and critical metabolic intermediates required for rapid cell proliferation
Furthermore, inhibition of phosphofructokinase-1 would lead to a buildup of fructose-6-phosphate, leading to a buildup of glucose-6-phosphate through phosphoglucose isomerase, which would be diverted to the pentose phosphate pathway, as it has been demonstrated 193,194
Well adjust your maintenance schedule based on your bodys response