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Indeed, buprenorphine, like morphine induces tolerance to analgesia without promoting MOR endocytosis, whereas etonitazene promotes less tolerance and has the ability to promote MOR internalization (Grecksch et al., 2006)

4- Muscle Regeneration and Anti-Atrophy Protection Preclinical work 6 shows IGF-1 regulates matrix metalloproteinases (MMPs) and cytokines during tissue remodeling, ensuring balanced regeneration and reducing fibrotic scarring.IGF-1 also demonstrates protective effects against muscle atrophy by suppressing ubiquitin-proteasome pathways, helping preserve lean mass even during inactivity

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Results revealed significant reductions in tibial nerve cross-sectional area (CSA), an indicator of nerve swelling, with 86% of participants exhibiting reduced CSA and 32% achieving normal nerve morphology [89]