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GLP-1 drugs are expensive enough to be out of reach for most people, unless they're covered by insurance

Exendin-4 (10 g/kg) treated SD rats by subcutaneous injection for 75 days, reduced body weight by approximately 30%, significantly reduced insulin, adiponectin, and leptin levels, but caused pancreatic acinar inflammation and pus toxicosis [7]

By inhibiting NF-kB activation, it could potentially reduce the inflammatory cascade that drives flare severity without compromising the immune response to concurrent infections, a common concern during lupus flares when patients may also be on immunosuppressive medications

Bilirubin also mitigates dopaminergic neuron injury by reducing iron deposition and activating the Nrf2 pathway