J Clin Endocrinol Metab 98:34023410 Sze L, Bernays RL, Zwimpfer C, Wiesli P, Brndle M, Schmid C (2012) Excessively high soluble klotho in patients with acromegaly
Examples Repaglinide (Prandin) Dosage Initial: 0.52 mg before each meal, up to four times daily Maximum: 16 mg daily, 4 mg per dose Nateglinide (Starlix) Dosage Initial: 60120 mg before meals, up to three times daily Maximum: 360 mg daily, 120 mg per dose Possible side effects include: Hypoglycemia (lower risk than sulfonylureas) Weight gain Bile acid sequestrants Primary mechanism(s) of action Bile acid sequestrants were originally developed and approved to lower LDL-cholesterol
In this way, we have a broader spectrum which is more conducive to the search for drug with a potentially sustained antidepressant effect
[PubMed] [Google Scholar] 87.Misra U.K., Kalita J., Das A