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Therapeutically, targeting adaptive immune pathwayssuch as restoring regulatory T cell (Treg) function, modulating Th17/Th1 responses, or influencing antigen presentationrepresents a potential adjunctive strategy to complement microbiome-directed and neuroprotective approaches, although its clinical efficacy remains to be fully established [88]

Rational dose selection and proper use of opioid drugs, through knowledge of their mechanisms of action, allow avoiding side effects related to their use

The ability of PEITC to alter the expression and activity of CYP enzymes has been generally associated with a protective effect against (pro)carcinogen-induced tumor development in animal experiments (reviewed in 24)