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Key points: GI side effects are most common: nausea, diarrhea, and decreased appetite They usually improve: most patients adapt within 4-8 weeks Start low, go slow: the escalation schedule exists for a reason Stay hydrated and modify your diet: simple changes make a big difference Communicate with your provider: don't suffer unnecessarily Sources SURMOUNT-1 Clinical Trial (Jastreboff et al., NEJM 2022) SURPASS-1 Clinical Trial (Rosenstock et al., NEJM 2021) Mounjaro Prescribing Information, Eli Lilly Zepbound Prescribing Information, Eli Lilly Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice

Here is some advice on talking to your doctor about starting a GLP-1, a guide to losing weight sans drugs, and an essay about ending generational weight shaming

Working with so-called XX mice embryos bred to develop into females they introduced the mutation into a section of DNA known as Enh13, which controls the activity of Sox9

Histone modification The DNA nucleotide sequence winds around histones through electrostatic interactions in the chromosome