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Seek urgent medical assistance if you develop: severe and persistent abdominal pain repeated vomiting or inability to keep fluids down swelling of the face, lips, tongue or throat difficulty breathing severe dizziness, confusion or fainting sudden loss or rapid deterioration of vision symptoms of severe low blood sugar when using insulin or a sulphonylurea Suspected adverse reactions can also be reported through the MHRA Yellow Card scheme

People with higher starting BMI Individuals with BMI above 40 often see faster absolute weight loss in the early phases, simply because a higher body weight means a larger caloric expenditure even at rest, and the same percentage reduction in food intake creates a larger absolute caloric deficit

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This integrated, triple-pathway mechanism represents a more comprehensive physiological approach compared to earlier incretin mimetics