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This metabolic rebalancing supports reduced body fat levels and improved body composition without altering appetite or blood glucose, highlighting its value in body recomposition and metabolic optimization research

Recent evidence showed that Tirzepatide (TZP), a new drug including both Glucagon Like Peptide 1 (GLP-1) and Glucose-dependent Insulinotropic Polypeptide (GIP) receptor agonism, is effective in subjects with type 2 diabetes (T2D), lowering body weight, fat mass and glycated hemoglobin (HbA 1c ) also in obese or overweight adults without T2D

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When restricting to injectable long-acting agents, heterogeneity decreased for most outcomes (MACE, CV mortality, all-cause mortality, and non-fatal MI), although the magnitude of reduction varied and was not directionally consistent across all outcomes (Supplementary Figure S3)