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SUSTAIN-6, 2016 GLP-1 receptor signaling in the hypothalamus and hindbrain modulates satiety and food-reward pathways, a focus of ongoing neuroscience research

Obrosova, I

Specific intervention scenarios of GLP-1 on cellular energy economics Treatment of diabetes: correcting the "imbalance of energy distribution" The core pathology of type 2 diabetes is insulin resistance and beta cell function failure, which leads to the imbalance of energy distribution: the intake of glucose by muscle and adipose tissue is reduced, the liver gluconeogenesis is increased, and the levels of glucose and FFA in the blood are increased, forming a vicious cycle of "hyperglycemia hyperlipidemia"

Calautti E, Avalle L, Poli V