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This study was one of the first to suggest that T cell recognition of insulin could rely on natural PTM, such as disulfide bond formation, rendering the molecule immunogenic and potentially triggering an autoimmune response (85)

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NPJ Regen Med

Patients with type 2 diabetes taking concurrent glucose-lowering medications, especially insulin or sulphonylureas, face increased hypoglycaemia risk, which can be particularly dangerous in older adults