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Small-molecule drugs including monocrotaline, doxorubicin, rifampicin, and phenytoin increased cell engraftment versus controls by causing hepatic endothelial damage (Wu et al., 2008)

Pickart L, Vasquez-Soltero JM, Margolina A

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That led us to wonder whether a compound with strong antioxidant capacity might protect HGF, either by preventing nitration or by compensating for the functional loss it causes. The team turned to two sulfur-based compounds known for strong antioxidant activity: glutathione trisulfide (GSSSG) and lipoic acid trisulfide (LASSS)