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Both are synthetic analogs of alpha-melanocyte-stimulating hormone (alpha-MSH) with the amino acid substitutions Nle4 and D-Phe7, which confer resistance to enzymatic degradation and enhanced MC1R receptor binding

Pernicious anaemia, a condition marked by the deficiency of vitamin B12 due to the inability of the body to absorb it, necessitates lifelong treatment to manage symptoms and prevent complications

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For instance, in the STEP 2 trial, nausea from semaglutide rose from 5% at week 1 to 15% by week 13, then decreased to 8% by week 68