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Available results from the Odyssey KIDS and HAUSER-RCT studies indicate the safety of PCSK9 inhibitors in the paediatric population and high efficacy (LDL-C reduction from 44.5 to 46%) [356, 357]
392,393,394 mTORC1 is sensitive to nutrients, such as glucose and amino acids, and is responsive to cellular stressors such as hypoxia and energy depletion, positioning it as a central regulator of cellular function
Once youve already got to one, the next step, from one to 10, is actually much easier
Even at 10x the effective dose, it barely touches those off-target hormones
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